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It doesn't play nice with a lot of popular Python libraries. In particular, many popular Python libraries (NumPy, Pandas, TensorFlow, etc.) rely on CPython’s C API which can cause issues.


FWIW, PyPy supports NumPy and Pandas since at least v5.9.

That said, of all the reasons stated here, it's why I don't primarily use PyPy (lots of libraries still missing)


But pypy doesn’t necessarily perform as well, and it can’t jit compile the already compiled C code in numpy, so any benefits are often lost.




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