What side effects cause people taking Metformin to discontinue it? I'm taking, but haven't noticed any, but... you don't notice your baseline, I suppose!
For diabetics, Metformin is usually a net win. Having controlled diabetes is better all around than uncontrolled.
For non-diabetics hoping Metformin will bring health benefits, the subtle side effects like reducing adaptive responses to exercise ( https://pmc.ncbi.nlm.nih.gov/articles/PMC6351883/ ) and other small negatives aren’t usually advertised by the anti-aging influencers who only talk about the lifespan studies (in mice)
Shitty shits. Literally. As for metabolic acidoses, rates are extremely low (<10 cases per 100,000 patient-years, per https://pubmed.ncbi.nlm.nih.gov/26773926/), so it's almost a non-concern.
I think this depends on the context. For your epidemiologist perspective, or looking at populations, that's a big rate! (Given how much metformin is taken) Would be easy to find people who suffer from it.
From the perspective of "Should I be worried about side effects from taking this drug / should I not take this because it might give me this effect", I think this falls under "be aware of symptoms and stop or weigh the costs if you get it, but you're probably fine".
