Someone with more domain knowledge, does this study hold water? Even perhaps as a reason to look further into the relationship between diet and Alzheimer’s?
I watched an interesting presentation on YouTube about how fructose is digested in the body, its totally different to glucose, and arguably more harmful becuase the liver can only handle so much, there are various metabolic products which also need to be dealt with... So I do believe this may be very plausible.
if you read Johnson's work, it's typically both. Direct fructose consumption as well as the polyol pathway being on and your body converting 'extra' glucose into fructose.
excess fructose (in particular in ultra-processed forms) causes metabolic derangement but consuming too much of those other 3 esp from ultra processed foods, also activates the "switch" leading to endogenous fructose production and more derangement.
The role of sedentarism in all this is somewhat under-explored though.
Probably "Sugar The Bitter Truth" by Lustig 2009 which was "controversial" at the time but more than a decade later its pretty much mainstream.
You're always going to have members of the general public and docs who don't keep upon on continuing nutritional education (snark, there isn't any) saying stuff that was out of date decades ago but I'd say the stuff in that video is pretty much mainstream now.
